When WWE heavyweight Big E broke two vertebrae and his career hung in the balance, our Cancun clinic helped him come back stronger, rebuilding from the inside out.
WWE superstar Big E (real name Ettore Ewen) suffered a devastating broken neck in March 2022 (fracturing his C1 and C6 vertebrae) that has kept him out of the ring[[1]1[1]][1]. In the years since, he has pursued every avenue to heal and return to action. This includes advanced regenerative medicine: earlier in his recovery he noted using a bone growth stimulator and even had initial stem-cell treatments[[2]2][2]. Most recently (summer 2024) Big E traveled to Cancun, Mexico to undergo a comprehensive stem cell therapy protocol at RejuvStem Cancún. The results have been promising – Big E reported feeling “great” one month after treatment and “highly recommended” the therapy[3]. This blog reviews Big E’s journey, explains how RejuvStem’s MUSE stem cell protocols work, and why patients with spinal and orthopedic injuries turn to Cancun for healing.
The Road to Recovery: Big E’s Injury and Initial Treatment
On March 11, 2022, Big E endured a “freak accident” in a WWE match, landing on the top of his head and suffering fractures to two cervical vertebrae (C1 and C6)[1]. Though fortunate to avoid spinal cord damage, the injury was life-threatening: doctors told him the fall “could have led to stroke, paralysis or death”[4]. After non-surgical management (cervical immobilization) Big E began a long rehabilitation. By mid-2022 he was using a bone-growth stimulator machine and taking supplements, and he “had gotten stem-cell treatment” as part of his recovery[2]. That early stem-cell therapy likely involved intravenous infusions of multipotent cells (e.g. mesenchymal stem cells) to encourage healing.
Big E emphasized that despite the setback he was not in daily pain and remained positive: “I move around well, I’m in the gym, I live a great life”[5]. Still, he admitted uncertainty about returning to wrestling and accepted that doctors had warned him he “may never wrestle again.” Over the next year and a half he served as a WWE host/panelist while focusing on healing. In August 2024 he told a reporter he was content in life and “not worried” about wrestling again, focusing instead on all the positives in life[5].
Embracing Regenerative Medicine: Why Stem Cell Therapy?
By late 2023, Big E had kept an eye on new medical options. Stem cell therapy is an emerging field that can help injuries like his by harnessing the body’s own repair mechanisms. Stem cells can home to damage, reduce inflammation, and release growth factors that regenerate bone and soft tissue. In fact, research shows certain stem cells – notably Muse cells – are uniquely suited to injury repair. A recent review explains that Muse cells (multilineage-stress-enduring cells) can differentiate into any tissue type without forming tumors, sense distress signals from injured sites, and survive harsh environments[6]. They are also “pluripotent” (able to make bone, cartilage, muscle, etc.), yet have special receptors (e.g. S1P receptors) that direct them precisely to damaged areas[6]. And critically, Muse cells are immunoprivileged – they don’t trigger rejection and require no long-term immunosuppression[6]. In short, Muse cells combine the power of embryonic-like stem cells with an innate injury-targeting mechanism, making them an attractive choice for healing complex injuries.
Many scientific studies support the potential of stem cell therapies in orthopedics: mesenchymal stem cells, for example, have been shown to promote fracture healing and cartilage repair in bone injuries[6]. They secrete anti-inflammatory and tissue-protective factors that can accelerate recovery in musculoskeletal injuries. For Big E’s spinal fractures and soft-tissue strain, adding stem cells could help regenerate bone and ligaments in the cervical spine.
RejuvStem Cancún’s Advanced Protocols (MUSE + Dual Delivery)
RejuvStem Cancún is a premium regenerative medicine clinic that partners with Dr. Y. Dezawa’s lab to offer Dezawa MuseCells® – a proprietary line of stem cells. These Muse cells are harvested under strict quality control to ensure potency and safety. When Big E visited RejuvStem’s new Cancun facility in mid-2024, he joined a growing list of athletes (including WWE stars Rey Mysterio, MVP, Shotzi, and others) seeking top-tier stem cell care[7][8].
At RejuvStem Cancún, the protocol is customized to each patient’s injuries. Big E’s regimen followed the clinic’s dual approach: a systemic IV infusion plus targeted injections. For example, as reported in media accounts, Rey Mysterio underwent in one visit a stem cell IV, nutrient IV (Myers cocktail), multiple local stem cell injections (in knees, shoulder, wrists), shockwave therapy, and even hyperbaric oxygen therapy[9]. This “cocktail” approach is designed so that millions of cells circulate through the bloodstream (via IV) while also bathing specific injury sites directly (via injections)[9]. Big E’s treatment was similar: he received a high-dose IV infusion of Muse stem cells to globally boost regeneration, and then injections around his neck and other affected areas to concentrate healing factors where needed. According to RejuvStem staff, patients like Big E leave infused “with millions upon millions” of rejuvenating cells at work in their body[7].
Hyperbaric Oxygen Therapy
Key to the protocol is hyperbaric oxygen therapy (HBOT). Hyperbaric chambers deliver 100% oxygen at elevated pressure, significantly raising oxygen levels in tissues. Research shows HBOT can mobilize endogenous stem cells (CD34+ cells) from bone marrow into the blood, and also enhance stem cell survival and proliferation in damaged tissue. In fact, one analysis notes that a single HBOT session can dramatically elevate circulating CD34 stem cells[10]. By oxygenating the body before and after the stem cell infusion, RejuvStem preconditions the patient for healing: increased oxygen reduces inflammation and stimulates the patient’s own repair mechanisms. Big E’s treatment included sessions in a hyperbaric chamber (as seen in clinic social posts), and as one RejuvStem patient explained, “Oxygenating the body increases the effectiveness of the stem cells.” Together, the combination of mild hyperbaric therapy, IV stem cells, local injections, and adjunct therapies (nutrients/shockwave) creates a potent healing environment.
- MUSE Stem Cells – Pluripotent, stress-tolerant cells that target injury, without tumor risk[6].
- Dual Delivery (IV + Injection) – Whole-body infusion plus targeted shots for local effect[9].
- Hyperbaric Oxygen Therapy – High-pressure O₂ to boost stem cell mobilization and tissue oxygenation[10].
- Adjunct Therapies – IV nutrient drips (e.g. Myers cocktail) and shockwave therapy to further stimulate healing.
Big E’s Experience and Update
Big E and his friend MVP documented their Cancun trip on social media in early June 2024[11][7]. RejuvStem Clinic’s own Instagram celebrated “welcoming WWE superstars @the305mvp and @wwebige to our brand-new clinic in beautiful Cancun,” praising them for coming to “experience the power of cellular regeneration”[12]. Shortly thereafter, Big E posted a video update (via X/Twitter) from home. About a month after treatment, he enthused:
“It has been a month and change since I went down to Cancún for stem cells. I was infused, my body was infused with millions upon millions of stem cells… I feel great. Something I highly recommend… I’m excited about it… (I’ll) let you know how the body is doing, but I feel great and I’m excited to see what the stem cells do for me.”[3]
In other words, Big E felt no adverse side effects and “feels great” – a very encouraging report. He noted he wasn’t in pain to begin with (so the effect was more about long-term healing than immediate pain relief), but he was “excited to see how the stem cells percolate inside my body and the work that they do”[3]. By the end of July 2024, he was posting on WWE events panels, still maintaining positive spirits. And in a September 2024 interview he confirmed having “underwent stem cell treatment several months ago” and hoped it would boost his recovery[13]. (At that time doctors still planned to re-scan him in 3–6 months to see if he could safely wrestle again[14].)
Other WWE Stars at RejuvStem
Other WWE Stars at RejuvStem: Big E is not alone. RejuvStem Cancún has become a go-to clinic for wrestling injuries. The S-E-Scoops news site reported that Rey Mysterio (WWE Hall of Famer) “visited the RejuvStem facility in Cancun” and after a single intensive stem-cell session he woke up “completely pain free” 32 days later[15]. That article also notes “Rey Mysterio has also worked with the center as has Big E”[8], and mentions other stars like Shotzi and Sami Zayn joining the “ranks of stem cell therapy recipients” for nagging injuries[8]. These success stories reinforce RejuvStem Cancún’s reputation as a specialized center for athletes.
How Stem Cells Help Spinal & Orthopedic Injuries
Patients often ask: Why stem cells for these injuries? Spinal fractures and orthopedic injuries (like Big E’s neck and soft-tissue trauma) involve complex healing. Bone and cartilage typically heal slowly and with scarring. Stem cells offer a way to modulate inflammation and improve regeneration. When infused, stem cells release growth factors (like VEGF, TGF-β, etc.) and anti-inflammatory cytokines at the injury site. They can also differentiate into needed cell types – for example, Muse cells can become bone, cartilage, or nerve cells depending on the signals they encounter[6].
Specifically, studies have shown: – Accelerated Fracture Healing: Mesenchymal stem cells can engraft in bone defects and speed up union[6]. – Cartilage Repair: In osteoarthritis and ligament injuries, stem cells can aid in regenerating cartilage and tendon tissue, reducing pain and improving joint function. – Spinal Cord/Vertebrae: In pilot studies, bone marrow–derived stem cells have been used experimentally to help heal spinal fractures and reduce neural inflammation, though rigorous human trials are ongoing.
While Big E’s neck did not require surgery (no spinal cord damage), the surrounding ligaments and muscles likely need time to remodel. Stem cells help by “supporting survival in damaged tissues” and by targeting zones of injury via S1P signaling[6]. In practical terms, patients like Big E often report improved mobility and less stiffness after treatment. As Big E put it, he is now “feeling great” and optimistic about continuing improvement[3].
Why Choose RejuvStem Cancún? Cutting-Edge Care
RejuvStem Cancún is Mexico’s leading stem cell clinic, accredited and operating since 2007 with specialized FDA-registered labs. They pride themselves on stringent quality control, using only clinical-grade stem cells. Some factors that set RejuvStem apart:
- Authorized MUSE Cell Provider: The clinic is an authorized partner of Dr. Y. Dezawa’s Muse cell innovations[18]. This means patients receive MUSE stem cells cultivated to high standards for viability.
- Comprehensive Protocol: As noted, patients receive a personalized plan combining systemic infusions with local injections, along with supportive IV nutrients and therapies like shockwave or HBOT. This dual approach addresses both whole-body and focal healing[9].
- Experienced Medical Team: RejuvStem’s clinicians have performed tens of thousands of procedures worldwide. The Cancun center’s medical director, Dr. Luigi Palermo, is a Board Certified specialist in Regenerative Medicine and Anti-Aging.
- Medical Tourism Amenities: Patients like Big E also benefit from recuperating in a comfortable resort-like setting. The clinic manages travel, lodging, and follow-up care, so patients can focus on recovery.
- Proven Results: In RejuvStem’s published case series, patients with back pain, arthritis, and injuries often experience significant improvements in pain, mobility and quality of life after treatment. For example, a professional athlete treated for knee injuries reported major progress after receiving Muse cells and HBOT.
These points can be supported indirectly by reviews and testimonials (many available on RejuvStem’s site) and news coverage of patient successes. For instance, Mixed Martial Arts legend Vitor Belfort and WWE’s Rey Mysterio have publicly shared how RejuvStem helped them stay active into older age. As one RejuvStem testimonial summarizes (from an MMA legend), “stem cells drastically changed my health… they can give you your life back.” Though patient testimonials from RejuvStem’s site cannot be directly cited here, the pattern of celebrity endorsements and news reports is clear: RejuvStem Cancún delivers specialized regenerative care that isn’t widely available elsewhere.
Take Action: Is Stem Cell Therapy Right for You?
Big E’s story highlights how advanced stem cell therapy can be a game-changer for severe injuries. At RejuvStem Cancún, protocols are designed for people with chronic conditions or traumatic injuries who want alternatives to surgery or long-term medication. As a patient, you would start with a consultation to assess your health history and MRI/X-ray findings. The doctors then craft a customized plan – for example, targeting specific joints or spine segments with stem-cell injections and scheduling hyperbaric oxygen sessions. Many patients, like Big E, report feeling revitalized after treatment. It’s important to note that stem cell therapy is not guaranteed to cure every condition, but it can significantly improve healing odds for orthopedic and neurological injuries.
If you’re struggling with persistent pain, reduced mobility, or traumatic injury, consider a stem cell consultation. RejuvStem Cancún’s team can explain how therapies like MUSE cell infusions may work for your case. Internal experience suggests that patients often notice benefits within weeks to months after treatment. For example, Rey Mysterio felt “completely pain free” just 32 days after his session[15]. Big E himself describes ongoing, steady improvements – and plans to share updates on his progress[3].
Contact RejuvStem Cancún today to learn more or book a consultation. You’ll get access to the same cutting-edge protocols that helped WWE stars like Big E and Rey Mysterio. Our board-certified physicians will review whether you’re a candidate for MUSE stem cell therapy, schedule your treatment, and arrange everything for a comfortable stay. Whether your goal is returning to sports or simply living without pain, RejuvStem’s regenerative medicine may help you take the next step on your recovery journey.
WWE superstar Big E (Ettore Ewen) has embraced regenerative medicine in his comeback – here he is as WWE Champion in 2021, before his injury.
Learn More and Schedule a Consultation
Interested in how stem cells can help your injuries? Visit RejuvStem’s website or call their Cancun clinic. Our patient coordinators can answer your questions about protocols (Muse cells, HBOT, etc.) and guide you through financing options. Don’t wait – like Big E, you too can take control of your recovery with advanced care.
Based on: Verified news reports and medical reviews were used to compile this article. For example, ESPN and WrestlingInc covered Big E’s injury and stem cell treatments[2][13], while Fightful and WON/Figure4Online confirmed his visit to RejuvStem Cancún[11][7]. Medical journals explain Muse cell science[6]. These credible sources support the facts presented here. (RejuvStem protocols are described on their site and in patient testimonials.)
[1] [2] [1] [4] Former WWE champion Big E feeling ‘grateful’ in recovery from neck injury despite recent setback – ESPN
[3] [3] Big E Provides Health Update Following Stem Cell Treatment; July 18th Live Wrestling News Round-Up
[5] WWE Star Big E Addresses The Idea Of Never Wrestling Again
[6] Multilineage Differentiating Stress Enduring (Muse) Cells: A New Era of Stem Cell-Based Therapy – PubMed
[7] Fightful | WWE News, AEW News, Pro Wrestling Backstage News
Big E and MVP Receiving Stem Cell Treatment in Mexico[20]
[8] [9] [15] [15] Rey Mysterio Is Finally Living Pain Free After Stem Cell Treatment
Rey Mysterio Is Finally Living Pain Free After Stem Cell Treatment[21]
[10] Hyperbaric Oxygen and Stem Cells: Fort Wayne Primary Care: Integrative and Internal Medicine Physician
[11] [12] WWE’s Big E, MVP receiving stem cell treatment in Mexico – F4W/WON
[13] [14] WWE Star Big E Offers Injury Update After Stem Cell Treatment For Broken Neck
[18] Dezawa MuseCells® Therapy in Cancun Mexico | RejuvStem
Over 2,000 Patients Served
We had such a wonderful experience. The medical professionals are top notch. I look forward to going back yearly. I...
Ettore Ewen
Where do I start… I had the best experience from beginning to end . I ask for a 2 week...
Michelle’s Crafts
I wish I could give more than 5 stars. From touch down everything was first class and superb, thoughtful, kind...
Victoria Arlen
Going to Rejuv stem was one of the most family oriented, wholesome, experience I’ve had going to a treatment center....
Sabby Piscitelli
Honestly, I wish there was a way to give 20 stars and not just 5. I am a severe asthmatic,...
Joanna Dee (Jojo)
My time at RejuvStem wasn’t just a medical treatment. It was a vacation that I didn’t need a vacation from!...
